2016
Type(s)Journal Article
AuthorsMaoyi Lai, Alicia Gonzalez-Martin, Anthony B. Cooper, Hiroyo Oda, Huyn Yong Jin, Jovan Shepherd, Linling He, Jiang Zhu, David Nemazee & Changchun Xiao
SourceNature Communications 2016 7
Urlhttp://dx.doi.org/10.1038/ncomms12207
Abstract
The molecular mechanisms that regulate B-cell development and tolerance remain incompletely understood. In this study, we identify a critical role for the miR-17∼92 microRNA cluster in regulating B-cell central tolerance and demonstrate that these miRNAs control early B-cell development in a cell-intrinsic manner. While the cluster member miR-19 suppresses the expression of Pten and plays a key role in regulating B-cell tolerance, miR-17 controls early B-cell development through other molecular pathways. These findings demonstrate differential control of two closely linked B-cell developmental stages by different members of a single microRNA cluster through distinct molecular pathways.
Technology Platform
Next-Generation Sequencing
Research Topics
B cell Repertoire Analysis