Home2022-09-26T14:52:42-07:00

Welcome to Dr. Jiang Zhu’s Lab

Founded in 2013, Dr. Zhu’s Lab is dedicated to advancing biomedical research, educating students, and fostering career opportunities for young scholars. We are a multidisciplinary team working together to address important scientific questions and innovate key platform technologies.

Research Focus

Antibody
Research

Combine single-cell microfluidics and library display with deep sequencing to discover functional antibodies.

LEARN MORE

Rational
Vaccine Design

Combine structure-based computational design with nanoparticle engineering to develop effective vaccines.

LEARN MORE

Neuroscience & Optogenetics

Reengineer endogenous ion channels and receptors to exert non-invasive optical control of neural functions.

LEARN MORE

Molecular
Complexes

Develop powerful, versatile computational tools to facilitate structural study of macromolecular assemblies.

LEARN MORE

HIV Nanoparticle Vaccine

Self-assembling nanoparticle + Stabilized envelope trimer = Prophylactic HIV vaccine

This animation depicts how one of our leading HIV-1 vaccine candidates is designed. Dihydrolipoyl acetyltransferase (E2p) from Bacillus stearothermophilus is a protein that can automatically assemble into a 60-meric nanoparticle with a diameter of 23.2 nm. After an HIV-1 envelope glycoprotein (Env) has been stabilized by our “uncleaved, prefusion-optimized (UFO)” design, it can be displayed on the E2p surface through gene fusion. The outcome is a nanoparticle vaccine of 40-60 nm in size with 20 native-like viral spikes on the surface poised for immune recognition.

Latest News

cGMP Process Kickoff Meeting

March 25th, 2019|

March 25, 2019 - NIH Division of AIDS (DAIDS), ABL Inc, Ufovax Inc and Dr. Zhu (on behalf of Scripps Research) held a kickoff meeting to start the cGMP process development for the HIV-1 nanoparticle [...]

Go to Top