Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies

Year
2013
Type(s)
Authors
Zhou, T. Zhu, Jiang Wu, X. Moquin, S. Zhang, B. Acharya, P. Georgiev, I. S. Altae-Tran, H. R. Chuang, G. Y. Joyce, M. G. Kwon, Y. D. Longo, N. S. Louder, M. K. Luongo, T. McKee, K. Schramm, C. A. Skinner, J. Yang, Y. Yang, Z. Zhang, Z. Zheng, A. Bonsignori, M. Haynes, B. F. Scheid, J. F. Nussenzweig, M. C. Simek, M. Burton, Dennis Koff, W. C. NISC Comparative Sequencing Program Mullikin, J. C. Connors, M. Shapiro, L. Nabel, G. J. Mascola, J. R. Kwong, P. D.
Source
Immunity 2013 39:245-258
Url
http://dx.doi.org/10.1016/j.immuni.2013.04.012

Highlights

  • VRC01-class antibodies from six donors exhibit remarkably similar HIV-1 recognition

  • NGS sequencing of six donors with VRC01-class antibodies reveals genetic requirements

  • Restricted gene usage for VRC01-class antibodies indicates single ancestor B cell

  • Elicitation of VRC01-class antibodies is reproducible