Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs

Year
2016
Type(s)
Authors
Maoyi Lai, Alicia Gonzalez-Martin, Anthony B. Cooper, Hiroyo Oda, Huyn Yong Jin, Jovan Shepherd, Linling He, Jiang Zhu, David Nemazee & Changchun Xiao
Source
Nature Communications  2016 7
Url
http://dx.doi.org/10.1038/ncomms12207

Abstract

The molecular mechanisms that regulate B-cell development and tolerance remain incompletely understood. In this study, we identify a critical role for the miR-1792 microRNA cluster in regulating B-cell central tolerance and demonstrate that these miRNAs control early B-cell development in a cell-intrinsic manner. While the cluster member miR-19 suppresses the expression of Pten and plays a key role in regulating B-cell tolerance, miR-17 controls early B-cell development through other molecular pathways. These findings demonstrate differential control of two closely linked B-cell developmental stages by different members of a single microRNA cluster through distinct molecular pathways.

 

Technology Platform

Next-Generation Sequencing

Research Topics

B cell Repertoire Analysis