HIV-1 Vaccine Development

Transplanting supersites of HIV-1 vulnerability

PLoS One 2014 9:e99881
Zhou, T. Zhu, Jiang Yang, Y. Gorman, J. Ofek, G. Srivatsan, S. Druz, A. Lees, C. R. Lu, G. Soto, C. Stuckey, J. Burton, Dennis Koff, W. C. Connors, M. Kwon, P. D.

Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

Nature Communications 2016 7
Kong, L. He, L. de Val, N. Vora, N. Morris, C. D. Azadnia, P. Sok, Devin Zhou, Bin Burton, Dennis Ward, Andrew Wilson, Ian Zhu, Jiang

Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles

Nature Communications 2016 7
He, L. de Val, N. Morris, C. D. Vora, N. Thinnes, T. C. Kong, L. Azadnia, P. Sok, Devin Zhou, Bin Burton, Dennis Wilson, Ian Nemazee, David Ward, Andrew Zhu, Jiang

Differential antibody responses to conserved HIV-1 neutralizing epitopes in the context of multivalent scaffolds and native-like gp140 trimers

mBio 2017 8:e00036-17
Morris, C. D., Azadnia, P., de Val, N., Vora, N., Honda, A., Giang, E., Saye-Francisco, K., Cheng, Y. S., Lin, X., Mann, C. J., Tang, J., Sok, D., et al.

HIV-1 vaccine design through minimizing envelope metastability

Science Advances21 Nov 2018 : eaau6769
He L, Kumar S, Allen JJ, Huang D, Lin X, Mann CJ, Saye-Francisco KL, Copps J, Sarkar A, Blizard GS, Ozorowski G, Sok D, Crispin M, Ward AB, Burton DR, Wilson IA*, Zhu J* (*Co-corresponding authors)

An MPER antibody neutralizes HIV-1 using germline features shared among donors

Nat Commun 10, 5389 (2019) doi:10.1038/s41467-019-12973-1
Lei Zhang, Adriana Irimia, Lingling He, Elise Landais, Kimmo Rantalainen, Daniel P. Leaman, Thomas Vollbrecht, Armando Stano, Daniel I. Sands, Arthur S. Kim, IAVI Protocol G Investigators, Pascal Poignard, Dennis R. Burton, Ben Murrell, Andrew B. Ward, Jiang Zhu, Ian A. Wilson & Michael B. Zwick