HIV-1 Vaccine Development

Transplanting supersites of HIV-1 vulnerability

PLoS One 2014 9:e99881
Zhou, T. Zhu, Jiang Yang, Y. Gorman, J. Ofek, G. Srivatsan, S. Druz, A. Lees, C. R. Lu, G. Soto, C. Stuckey, J. Burton, Dennis Koff, W. C. Connors, M. Kwon, P. D.

Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

Nature Communications 2016 7
Leopold Kong, Linling He, Natalia de Val, Nemil Vora, Charles D. Morris, Parisa Azadnia, Devin Sok, Bin Zhou, Dennis R. Burton, Andrew B. Ward, Ian A. Wilson & Jiang Zhu

Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles

Nature Communications 2016 7
Linling He, Natalia de Val, Charles D. Morris, Nemil Vora, Therese C. Thinnes, Leopold Kong, Parisa Azadnia, Devin Sok, Bin Zhou, Dennis R. Burton, Ian A. Wilson, David Nemazee, Andrew B. Ward & Jiang Zhu

Differential antibody responses to conserved HIV-1 neutralizing epitopes in the context of multivalent scaffolds and native-like gp140 trimers

mBio 2017 8:e00036-17
Charles D. Morris, Parisa Azadnia, Natalia de Val, Nemil Vora, Andrew Honda, Erick Giang, Karen Saye-Francisco, Yushao Cheng, Xiaohe Lin, Colin J. Mann, Jeffrey Tang, Devin Sok, Dennis R. Burton, Mansun Law, Andrew B. Ward, Linling He, Jiang Zhu

HIV-1 vaccine design through minimizing envelope metastability

Science Advances21 Nov 2018 : eaau6769
Linling He, Sonu Kumar, Joel D. Allen, Deli Huang, Xiaohe Lin, Colin J. Mann, Karen L. Saye-Francisco, Jeffrey Copps, Anita Sarkar, Gabrielle S. Blizard, Gabriel Ozorowski, Devin Sok, Max Crispin, Andrew B. Ward, David Nemazee, Dennis R. Burton, Ian A. Wilson and Jiang Zhu

An MPER antibody neutralizes HIV-1 using germline features shared among donors

Nat Commun 10, 5389 (2019) doi:10.1038/s41467-019-12973-1
Lei Zhang, Adriana Irimia, Linling He, Elise Landais, Kimmo Rantalainen, Daniel P. Leaman, Thomas Vollbrecht, Armando Stano, Daniel I. Sands, Arthur S. Kim, IAVI Protocol G Investigators, Pascal Poignard, Dennis R. Burton, Ben Murrell, Andrew B. Ward, Jiang Zhu, Ian A. Wilson & Michael B. Zwick

Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with HCV envelope glycoproteins

Chen et al., 2021, Immunity 54, 1-16; https://doi.org/10.1016/j.immuni.2021.02.013
Fang Chen, Netanel Tzarum, Xiaohe Lin, Erick Giang, Rodrigo Velazquez-Moctezume, Elias H. Augestad, Kenna Nagy, Linling He, Mayda Hernandez, Mallorie E. Fouch, Ariadna Grinyo, Deborah Chavez, Benjamin J. Doranz, Jannick Prentoe, Robyn L. Stanfield, Robert Lanford, Ian A. Wilson, Jiang Zhu, Mansun Law

Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimers as HIV-1 vaccine candidates

Nature Communications Volume 14, Article number: 1985 (2023)
Yi-Nan Zhang, Jennifer Paynter, Aleksandar Antanasijevic, Joel D. Allen, Mor Eldad, Yi-Zong Lee, Jeffrey Copps, Maddy L. Newby, Linling He, Deborah Chavez, Pat Frost, Anna Goodroe, John Dutton, Robert Lanford, Christopher Chen, Ian A. Wilson, Max Crispin, Andrew B. Ward & Jiang Zhu